"Too bad," says Jimb. "Hey, friends!" and bolts. You see two people run out from behind cover and towards Lou's house; you don't know what they're planning. However, you can guess the plans of the other four who are now in plain view, looking at you and drawing weapons.
Take care of the closer thugs. Throw your weapon at the further thugs. Maybe saving Lou is more important. Compromise between those two. Break a line to the further thugs, get rid of them, then take care of the rest, still armed.