"What was all that about?" you ask. "Some of the Stonemasons turned into the Defias," he says. "Now they want all the old Stonemasons complicit or dead." He looks nervously over his shoulder. "All of us." Then he starts shaking, yells, "I swear, I'm still loyal! He's in there, I swear!" and bolts. You see two people run out from behind cover and towards Lou's house. Another four are now in plain view, looking at you and drawing weapons.
Take care of the closer thugs. You can't do anything more for this place if they kill you. Throw your weapon at the further thugs. Maybe saving Lou is more important. Compromise between those two. Break a line to the further thugs, get rid of them, then take care of the rest, still armed.